Stem Cell Medicine Manufacturing MSC-Derived Exosomes for Treatment of Autism

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If you’re just hearing about stem cell therapy for autism, then this innovative therapy and its related terminology can be confusing. However, by understanding stem cell products and their production, you can feel more comfortable with this therapy and feel assured that you’re getting a safe and effective treatment.

Keep reading to learn about MSC-derived exosomes, including what they are, how they are made and their potential in treating autism.

Potential of Exosomes from Human MSCs in Alleviating Symptoms of Autism

What are Exosomes?

Exosomes are vesicles produced inside of cells for the purpose of transporting substances between cells. They also transmit signals that cause behavioral changes in other cells, making them an excellent method to deliver the therapeutic effect of MSCs.

Exosomes circulate the blood, allowing them to reach all areas of the body and influence many different cells in the body. For this reason, stem cell clinics use stem cell exosomes as part of their therapy. In general, stem cell exosomes have the following therapeutic effects:

  • stimulate differentiation
  • activate proliferation
  • regulate cell regeneration
  • facilitate the survival of local cells

Exosome therapy can help restore the function of many different tissues, including muscle, bone and nerve tissue.

How Do MSC-Derived Exosomes Benefit Autism?

Stem Cell Medicine Limited has shown through mice models that MSCs derived from bone marrow can result in long-lasting improvements for autism. They also show that MSC-derived exosomes may be the primary mediators of this therapeutic effect.

MSC exosomes can also penetrate the blood-brain barrier, facilitating differentiation and growth of neurons and suppressing neuroinflammation. This makes MSC-derived exosome therapy an excellent fit for neurological conditions like autism.

MSC-derived exosomes also promote the production of cytokines that suppress neuroinflammation, another reason why exosome therapy can treat neurological conditions like autism.

The immunomodulatory effects of MSC exosomes make them an increasingly attractive therapy for immune disorders. As the connection between the immune system and autism is gaining more acceptance, more people are using MSC exosome therapy to treat underlying immune disorders in people with autism.

Using Exosomes to Address Autism-Related Behaviors

Research has shown that the administration of bone marrow MSCs improves autism-related behaviors in mice in the long term. Studies pointed to MSC exosomes as being the primary meditators of this therapeutic effect, so researchers tested the effect of MSC-derived exosomes on autism-related behaviors.

When MSC-derived exosomes were administered to mice, they showed significant improvement in social interactions and ultrasonic vocalizations. Researchers also observed fewer repetitive behaviors and improved maternal behaviors in the mice.

Impairment of social interactions is one of the most debilitating symptoms in people with autism. Repetitive behaviors are another trademark of autism and can be extremely limiting for people with the disease. This can include repetitive motor movements, extreme interest in certain topics, and inability to change routines.

Therefore, by improving these autism-related behaviors, MSC exosome therapy can significantly improve the quality of life of people with autism, making it a promising autism treatment.

Some other positive effects of MSC-derived exosomes for autism include:

  • Improved eye contact
  • Better behavior at home
  • Increased attention span
  • Better self-care
  • Reduced gastrointestinal issues
  • Improved verbal communication.

Production Process of Stem Cell-Derived Exosome

At many stem cell clinics, including Swiss Medica, MSC exosomes can be extracted from either the recipient’s own cells or from donor cells.

With donor cells, patients can begin therapy immediately and since donor cells often come from the umbilical cord or placenta, donor cells may be more healthy than the recipient’s cells.

Stem cell-derived exosomes are produced in a safe and ethical way. First, MSCs are isolated and grown in a culture, until a sufficient quantity of MSC exosomes is reached. The exosomes are then extracted from the culture and go through testing and quality analysis to ensure they are safe and suitable for treatment.

In Conclusion

MSC-derived exosomes are emerging as an effective autism treatment, due to their ability to travel throughout the body and interact with cells to stimulate differentiation and cell regulation.

Studies on mice have shown how MSC exosomes deliver the therapeutic properties of MSCs to improve autism symptoms. MSC-derived exosomes have been shown to improve social interaction and reduce repetitive behaviors, but improvements such as improved sleep, self-care, and attention span are also possible.

Claire S. Allen
Claire S. Allen
Hi there! I'm Claire S. Allen, a vibrant Gemini who's as bold as my favorite color, red. I'm a fan of two cool things: strolling the streets in a red jacket and crafting articles that connect with readers. With my warm and friendly personality, Claire is sure to brighten up your day!
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